Donepezil hydrochloride monohydrate , 98% , 120014-06-4

CAS NO.：120014-06-4

Empirical Formula: C24H29NO3

Molecular Weight: 379.49

MDL number: MFCD00912833

EINECS: 601-651-9

PRODUCT Properties

• Melting point: 207°C
• Boiling point: 527.9±50.0 °C(Predicted)
• Density: 1.141±0.06 g/cm3(Predicted)
• storage temp.: Sealed in dry,Room Temperature
• solubility: Acetone (Slightly), Chloroform (Slightly)
• form: Solid
• pka: 8.84±0.10(Predicted)
• color: White to Off-White
• Water Solubility: 2.931 mg/L
• InChI: InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3
• InChIKey: ADEBPBSSDYVVLD-UHFFFAOYSA-N
• SMILES: C1(=O)C2=C(C=C(OC)C(OC)=C2)CC1CC1CCN(CC2=CC=CC=C2)CC1
• CAS DataBase Reference: 120014-06-4(CAS DataBase Reference)

Description and Uses

Donepezil is another “nonclassic,” centrally acting, reversible, noncompetitive AChEI that was approved in 1997 for treatment of mild-to-moderate AD and dementia. Its selectivity for AChE is 570- to 1,250-fold that for butyrylcholinesterase, and it also exhibits greater affinity for brain AChE than for AChE in the periphery.

Donepezil is a cholinesterase inhibitors.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36-36/37/39
• RIDADR: UN 2811
• HS Code: 29333990
• Hazardous Substances Data: 120014-06-4(Hazardous Substances Data)