Dyclonine hydrochloride , ≥99% , 536-43-6
Synonym(s):
1-(4-Butoxyphenyl)-3-(1-piperidinyl)-1-propanone;Dyclonine hydrochloride
CAS NO.：536-43-6
Empirical Formula: C18H28ClNO2
Molecular Weight: 325.87
MDL number: MFCD00035386
EINECS: 208-633-6
| Pack Size | Price | Stock | Quantity |
| 5G | RMB129.60 | In Stock |
|
| 100G | RMB1604.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 175-176°C |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Soluble in DMSO (20 mg/ml); Water (25 mg/ml) |
| form | solid |
| color | White |
| Water Solubility | Partly soluble in water. Soluble in chloroform, ethanol, acetone and methanol. |
| Merck | 14,3473 |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months. |
| InChI | InChI=1S/C18H27NO2.ClH/c1-2-3-15-21-17-9-7-16(8-10-17)18(20)11-14-19-12-5-4-6-13-19;/h7-10H,2-6,11-15H2,1H3;1H |
| InChIKey | KNZADIMHVBBPOA-UHFFFAOYSA-N |
| SMILES | C1(C(=O)CCN2CCCCC2)C=CC(OCCCC)=CC=1.Cl |
| CAS DataBase Reference | 536-43-6(CAS DataBase Reference) |
Description and Uses
Dyclonine (536-43-6) is a? topical anesthetic which has been used for oral and throat analgesia.1 Enhances neuronal mitochondrial function, potentiating respiration and providing protection against insults associated with neurodegenerative disorders.2 Inhibits aldehyde dehydrogenase ALDH3A1 resulting in accumulation of 4-hydroxynonenal, which renders head and neck squamous cell carcinoma cells sensitive to the cystine-glutamate antiporter inhibitor, sulfasalazine.3 Rescues frataxin deficiency in animal models as well as in buccal cells of patients with Friedreich’s Ataxia.4 Enhances the cytotoxic effect of proteasome inhibitors MG-1325 and bortezomib6 in cancer cells.
Dyclonine hydrochloride is used for the temporary relief of the following occasional mouth and throat symptoms: pain, minor irritation, sore mouth and sore throat. It is a sodium channel blocker and a HSP90 chaperone protein inhibitor. It shows local anesthetic effects in vivo and is orally active.
Safety
| Symbol(GHS) |   GHS05,GHS06 |
| Signal word | Danger |
| Hazard statements | H301-H315-H318-H335 |
| Precautionary statements | P261-P264-P280-P301+P310-P302+P352-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-37/38-41 |
| Safety Statements | 26-36 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| RTECS | UG8750000 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 2933399090 |
