Chelerythrine chloride , 98% , 3895-92-9

Synonym(s):
Chelerythrine Chloride - CAS 3895-92-9 - Calbiochem

CAS NO.：3895-92-9

Empirical Formula: C21H18ClNO4

Molecular Weight: 383.82

MDL number: MFCD00060717

EINECS: 223-444-9

PRODUCT Properties

• Melting point: 195-205 °C
• storage temp.: Inert atmosphere,Store in freezer, under -20°C
• solubility: DMSO: ≥10 mg/mL
• form: powder
• color: yellow to orange
• Water Solubility: water: 1mg/mL; DMSO: 10mg/mL
• Stability: Hygroscopic
• InChI: 1S/C21H18NO4.ClH/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22;/h4-10H,11H2,1-3H3;1H
• InChIKey: WEEFNMFMNMASJY-UHFFFAOYSA-M
• SMILES: Cl.COc1ccc2-c3ccc4cc5OCOc5cc4c3[N](C)=Cc2c1OC

Description and Uses

Chelerythrine is a potent, cell permeable inhibitor of protein kinase C (IC₅₀ = 660 nM) that does not inhibit tyrosine protein kinases, cAMP-dependent protein kinase, or calcium/calmodulin-dependent protein kinase. Chelerythrine also inhibits Bcl-xL function (IC₅₀ = 1.5 μM) by displacing Bax binding, inducing apoptosis in several cancer cell lines. Chelerythrine can also have PKC-independent effects, activate p38 MAP kinase and JUNK signaling pathways, and induce apoptosis in cancer cells both in vitro and in vivo.

Chelerythrine Chloride is a cell permeable protein kinase C (PKC) inhibitor.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302+H312+H332-H315-H319-H335
• Precautionary statements: P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338
• target organs: Respiratory system
• Hazard Codes: Xn,Xi
• Risk Statements: 20/21/22-36/37/38-36/37
• Safety Statements: 26-36-36/37
• RIDADR: UN 1544PSN1 6.1 / PGII
• WGK Germany: 3
• RTECS: FL9200000
• HS Code: 29349990
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Acute Tox. 4 Dermal; Acute Tox. 4 Inhalation; Acute Tox. 4 Oral; Eye Irrit. 2; Skin Irrit. 2; STOT SE 3
• Toxicity: mouse,LD50,intravenous,18500ug/kg (18.5mg/kg),Planta Medica. Vol. 43, Pg. 161, 1981.