A6966258
D-erythro-sphingosine , 10mMinDMSO , 123-78-4
Synonym(s):
Sphingosine;D-erythro-sphingosine;Sphingosine 2S, 3R; D-erythro-Sphingosine; (2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol; (2S,3R,4E)-2-amino-1,3-octadec-4-enediol;(2S,3R,4E)-2-Amino-4-octadecene-1,3-diol;trans-D -erythro-2-Amino-4-octadecene-1,3-diol
CAS NO.：123-78-4
Empirical Formula: C18H37NO2
Molecular Weight: 299.49
MDL number: MFCD00036751
EINECS: 204-651-3
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB559.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 74.2-78.1 °C |
| Boiling point: | 440.8°C (rough estimate) |
| Density | 0.9758 (rough estimate) |
| refractive index | 1.5000 (estimate) |
| storage temp. | -20°C |
| solubility | chloroform: 20 mg/mL, clear, colorless to very faintly yellow |
| pka | 11.80±0.45(Predicted) |
| form | Powder or Waxy Solid |
| color | White to cream |
| biological source | synthetic |
| Merck | 14,8747 |
| BRN | 1727294 |
| Stability: | Stable. Incompatible with strong acids, strong bases, strong oxidizing agents. |
| InChIKey | WWUZIQQURGPMPG-KRWOKUGFSA-N |
| CAS DataBase Reference | 123-78-4 |
Description and Uses
Sphingosine (123-78-4) is an inhibitor of protein kinase C (IC50 = 1-3 μM).1 It is abundant in cell membranes and is an important mediator in various biochemical pathways.2-4
Sphingosine (d18:1) has been used:
- for sphingosine inhalations studies in mice to evaluate its therapeutic potential in respiratory epithelial cells
- to investigate its effect on Pseudomonas aeruginosa strains
- as a standard in liquid chromatography tandem mass spectrophotometry for the quantification of epidermal ceramides
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P271-P280 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| F | 1-8-10 |
| HS Code | 29221985 |
