Etoposide , 98% , 33419-42-0
Synonym(s):
4′-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-β-D -glucopyranoside);Etoposide;VP16;VP-16
CAS NO.：33419-42-0
Empirical Formula: C29H32O13
Molecular Weight: 588.56
MDL number: MFCD00869325
EINECS: 251-509-1
| Pack Size | Price | Stock | Quantity |
| 100MG | RMB39.20 | In Stock |
|
| 250MG | RMB51.20 | In Stock |
|
| 500MG | RMB95.20 | In Stock |
|
| 1G | RMB158.40 | In Stock |
|
| 5G | RMB759.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 236-251 °C (lit.) |
| Boiling point: | 563.9°C (rough estimate) |
| alpha | D20 -110.5° (c = 0.6 in chloroform) |
| Density | 1.2966 (rough estimate) |
| refractive index | -110.5 ° (C=0.6, CHCl3) |
| storage temp. | 2-8°C |
| solubility | DMSO: 30 mg/mL |
| form | powder |
| pka | 9.8(at 25℃) |
| color | white |
| biological source | synthetic |
| Water Solubility | Insoluble in water. |
| Merck | 14,3886 |
| BCS Class | 4 |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months |
| IARC | 1 (Vol. 76, 100A) 2012, 1 (Vol. 76, 100A) 2012 |
| EPA Substance Registry System | Etoposide (33419-42-0) |
Description and Uses
Etoposide is a plant alkaloid and an inhibitor of topoisomerase II (IC50 = 60.3 μM). It inhibits proliferation of a variety of adenocarcinoma cells (IC50s = 0.005-12,200 μM) and human umbilical vein endothelial (HUVEC) cells (IC50 = 0.249 μM). It reduces tumor growth in an Ma human embryonal carcinoma mouse xenograft model when administered at a dose of 25 mg/kg, an effect that is enhanced by concomitant administration of the immunosuppressant cyclosporin A . Etoposide also inhibits nuclear receptor coactivator 3 (IC50 = 2.48 μM). Formulations containing etoposide have been used in combination therapy in the treatment of cancer.
Etoposide is used for germinogenic tumors, ovarian, stomach, and lung cancer, Hodgkin’s disease, and non-Hodgkin’s lymphoma for both monotherapy and in combination therapy.
Safety
| Symbol(GHS) |   GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H302-H350-H361d-H412 |
| Precautionary statements | P201-P280-P301+P312+P330-P308+P313 |
| Hazard Codes | T,Xi |
| Risk Statements | 45-22-36/37/38 |
| Safety Statements | 53-45-36/37-26 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| RTECS | KC0190000 |
| HazardClass | 6.1(a) |
| PackingGroup | II |
| HS Code | 29389090 |
| Hazardous Substances Data | 33419-42-0(Hazardous Substances Data) |
| Toxicity | LD50 oral in rabbit: 147mg/kg |
