0 , 95% , 189028-95-3

CAS NO.：189028-95-3

Empirical Formula: C20H20FNO4

Molecular Weight: 357.38

MDL number: MFCD13194798

EINECS: 606-165-0

PRODUCT Properties

• Boiling point: 572.7±50.0 °C(Predicted)
• Density: 1.297
• storage temp.: 2-8°C
• solubility: Chloroform (Sparingly), Methanol (Slightly)
• form: Solid
• pka: 14.17±0.20(Predicted)
• color: White to Off-White
• InChI: InChI=1S/C20H20FNO4/c21-16-11-9-15(10-12-16)18(23)7-4-8-19(24)22-17(13-26-20(22)25)14-5-2-1-3-6-14/h1-3,5-6,9-12,17-18,23H,4,7-8,13H2/t17-,18+/m1/s1
• InChIKey: AVAZNWOHQJYCEL-MSOLQXFVSA-N
• SMILES: O1C[C@H](C2=CC=CC=C2)N(C(=O)CCC[C@@H](C2=CC=C(F)C=C2)O)C1=O

Description and Uses

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1, 3-OXAZOLIDIN-2-ONE is a derivative of 2-oxazolidine, which is an effective antimicrobial. It can be used as a pharmaceutical intermediate for the preparation of ezetimibe which is a drug used to lower the patients’ plasma cholesterol levels.

3-[(5S)-(4-Fluorophenyl)-5-hydroxypentanoyl]-(4S)-phenyl-1,3-oxazolidin-2-one is an intermediate of Ezetimibe (E975000, E975002), an antihyperlipoproteinemic. A cholesterol absorption inhibitor.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P301+P312-P302+P352-P304+P340-P305+P351+P338