Fluvoxamine maleate , ≥98% , 61718-82-9

Synonym(s):
(E)-5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone-O-(2-aminoethyl)oxime maleate;Fluvoxamine maleate

CAS NO.：61718-82-9

Empirical Formula: C19H25F3N2O6

Molecular Weight: 434.41

MDL number: MFCD00269809

EINECS: 612-212-6

PRODUCT Properties

• Melting point: 120-121.5 °C
• Flash point: 9℃
• storage temp.: 2-8°C
• solubility: H₂O: soluble
• form: solid
• color: White to Off-White
• Water Solubility: Soluble in water (10mM)
• Merck: 14,4219
• BCS Class: 1
• InChIKey: LFMYNZPAVPMEGP-PIDGMYBPSA-N
• SMILES: C(C1C=CC(=CC=1)/C(=N\OCCN)/CCCCOC)(F)(F)F.C(O)(=O)/C=C\C(O)=O
• CAS DataBase Reference: 61718-82-9(CAS DataBase Reference)

Description and Uses

Fluvoxamine maleate is the most recent of the serotonin-specific antidepressants to reach the market. In vitro and in vivo animal experiments have shown fluvoxamine to have a marked effect on 5-HT mediated processes and little effect on norepinephrine. Clinical trials suggest similar efficacy to imipramine and clomipramine with a somewhat lower incidence of side effects, especially anticholinergic effects. Fluvoxamine, in contrast to the tricyclic antidepressants, does not appear to produce heart rate increase, postural hypotension or prolongation of the intraventricular conduction time and QT interval.

Fluvoxamine maleate has been used as a test compound to determine the solubility and effective blood-brain barrier permeability.(2)

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P301+P312+P330
• Hazard Codes: Xn,Xi
• Risk Statements: 22-36/37/38
• Safety Statements: 36-36/37/39-27-26
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 3
• RTECS: SA9230000
• HS Code: 29280000