A4372912
Fmoc-tBu-Gly-OH , ≥98.0% , 132684-60-7
Synonym(s):
Fmoc-α-t-butylglycine;Fmoc-L -tert-leucine;Fmoc-Tle-OH;N-α-Fmoc-L-α-t.-butyl-glycine, Fmoc-Tle-OH
| Pack Size | Price | Stock | Quantity |
| 1G | RMB31.20 | In Stock |
|
| 5G | RMB39.20 | In Stock |
|
| 25g | RMB115.20 | In Stock |
|
| 100g | RMB343.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 124-127 °C |
| Boiling point: | 554.1±33.0 °C(Predicted) |
| Density | 1.209±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | ≥ 35.3mg/mL in DMSO, ≥ 49.6 mg/mL in EtOH |
| pka | 3.92±0.10(Predicted) |
| form | powder to crystal |
| color | White to Light yellow |
| BRN | 6662856 |
| Major Application | peptide synthesis |
| InChI | 1S/C21H23NO4/c1-21(2,3)18(19(23)24)22-20(25)26-12-17-15-10-6-4-8-13(15)14-9-5-7-11-16(14)17/h4-11,17-18H,12H2,1-3H3,(H,22,25)(H,23,24)/t18-/m1/s1 |
| InChIKey | VZOHGJIGTNUNNC-GOSISDBHSA-N |
| SMILES | CC(C)(C)[C@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(O)=O |
| CAS DataBase Reference | 132684-60-7(CAS DataBase Reference) |
Description and Uses
Fmoc-Tle-OH is a versatile reactant used in the discovery of potent antagonists of antiapoptotic protein X-linked inhibitor of apoptosis (XIAP) for treatment of cancer. It is also used as reactant in the preparation of phosphino dipeptide derivatices as ligand in copper-phosphine catalyst for asymmetric conjugate addition of alkylzinc reagents to unsaturated ketones.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 29242990 |
| Storage Class | 11 - Combustible Solids |
