α-Galactosyl Ceramide Supplier: Funakoshi Co. Ltd. , ＞95% , 158021-47-7

Synonym(s):
α-Galactosyl Ceramide;α-Galactosylceramide;α-GalCer;KRN7000

CAS NO.：158021-47-7

Empirical Formula: C50H99NO9

Molecular Weight: 858.32

MDL number: MFCD00939559

PRODUCT Properties

• Melting point: 125-130°C
• Boiling point: 939.8±65.0 °C(Predicted)
• Density: 1.04±0.1 g/cm3(Predicted)
• storage temp.: -20°C Freezer
• solubility: Pyridine (Slightly, Heated)
• form: White solid.
• pka: 12.92±0.70(Predicted)
• color: White to Pale Beige
• Stability: Hygroscopic
• CAS DataBase Reference: 158021-47-7

Description and Uses

KRN 7000 is a potent synthetic α-galactosylceramide, which, in association with the antigen-presenting CD1d protein, activates NKT immune cells. As these cells have important roles in the rejection of malignant tumors and in the regulation of several autoimmune diseases, KRN 7000 has activity in many diseases, including cancer, lupus, diabetes, malaria, and tuberculosis.

Galactosylceramides play an important roles in promoting the regulation of nerve cells, regulating protein kinase C activities and modulating the function of the hormone receptor. It has shown to have significant immunostimulatory and anti-umor activity in mice with liver metastasis of the Colon26 adenocarcinoma.

Safety

• WGK Germany: 3
• HS Code: 2940.00.6000