Ketoconazole , ≥98% , 65277-42-1
Synonym(s):
(±)-cis-1-Acetyl-4-(4-[(2-[2,4-dichlorophenyl]-2-[1H-imidazol-1-ylmethyl]-1,3-dioxolan-4-yl)-methoxy]phenyl)piperazine;cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine, R-41400, CYP17A1 Inhibitor I;Ketoconazole;Ketoconazole - CAS 65277-42-1 - Calbiochem
CAS NO.：65277-42-1
Empirical Formula: C26H28Cl2N4O4
Molecular Weight: 531.43
MDL number: MFCD00058579
EINECS: 265-667-4
| Pack Size | Price | Stock | Quantity |
| 1G | RMB24.00 | In Stock |
|
| 5G | RMB37.60 | In Stock |
|
| 25G | RMB149.60 | In Stock |
|
| 100G | RMB499.20 | In Stock |
|
| 500g | RMB2044.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 148-152 °C |
| Boiling point: | 753.4±60.0 °C(Predicted) |
| Density | 1.4046 (rough estimate) |
| refractive index | -10.5 ° (C=0.4, CHCl3) |
| Flash point: | 9℃ |
| storage temp. | 2-8°C |
| solubility | methanol: soluble50mg/mL |
| pka | pKa 3.25/6.22(H2O,t =25,I=0.025) (Uncertain) |
| form | Off-white solid |
| color | white to light yellow |
| optical activity | [α]20/D -1 to 1°, c = 4 in methanol |
| Water Solubility | Soluble in DMSO, ethanol, chloroform, water, and methanol. |
| Merck | 14,5302 |
| BCS Class | 2 |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| InChIKey | XMAYWYJOQHXEEK-OZXSUGGESA-N |
| LogP | 4.350 |
| CAS DataBase Reference | 65277-42-1(CAS DataBase Reference) |
Description and Uses
Ketoconazole (Nizoral), an orally effective broadspectrum antifungal agent, blocks hydroxylating enzyme systems by interacting with cytochrome P450 at the heme iron site to inhibit steroid and/or androgen synthesis in adrenals, gonads, liver, and kidney. The most sensitive site of action appears to be the C17-20 lyase reaction involved in the formation of sex steroids. This explains the greater suppressibility of testosterone production than with cortisol. Cholesterol side-chain cleavage and 11β/18-hydroxylase are secondary sites of inhibition.
An inhibitor of CYP proteins, thromboxane synthetase, and 5-LO
Safety
| Symbol(GHS) |    GHS06,GHS08,GHS09 |
| Signal word | Danger |
| Hazard statements | H301-H360F-H373-H410 |
| Precautionary statements | P201-P202-P260-P264-P273-P301+P310 |
| Hazard Codes | T,N,F |
| Risk Statements | 25-36/37/38-23/24/25-50/53-48/22-60-39/23/24/25-11 |
| Safety Statements | 36-45-36/37/39-26-61-60-53-36/37-16-7 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | TK7912300 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29349990 |
| Hazardous Substances Data | 65277-42-1(Hazardous Substances Data) |
| Toxicity | LD50 in mice, rats, guinea pigs, dogs (mg/kg): 44, 86, 28, 49 i.v.; 702, 227, 202, 780 orally (Heel) |
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) |
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) |
