A5294212
LY364947 , ≥98% , 396129-53-6
Synonym(s):
;4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-quinoline;Transforming Growth Factor-β Type I Receptor Kinase Inhibitor
| Pack Size | Price | Stock | Quantity |
| 5MG | RMB302.40 | In Stock |
|
| 10MG | RMB515.20 | In Stock |
|
| 50MG | RMB2105.60 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | >230℃ (dec.) |
| Boiling point: | 490.8±45.0 °C(Predicted) |
| Density | 1.283±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble2mg/mL, clear |
| pka | 8.94±0.50(Predicted) |
| form | powder |
| color | white to beige |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| InChI | InChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21) |
| InChIKey | IBCXZJCWDGCXQT-UHFFFAOYSA-N |
| SMILES | N1C2C(=CC=CC=2)C(C2=CNN=C2C2=NC=CC=C2)=CC=1 |
Description and Uses
LY-364947 (396129-53-6) is a selective ALK5 inhibitor, IC50 = 59, 400 and 1400 nM for TGF-β RI, TGF-β RII and MLK-7K, respectively.1 Inhibits Smad2 phosphorylation induced by TGF-β as well as fibronectin expression and MDA-MB-231 cell invasion.2 LY-364947 abolishes resistance of glioblastoma-initiating cells to radiation.3?Cell permeable.
LY 364947, is a potent ATP-competitive inhibitor of Tgf-b signaling.
Safety
| Symbol(GHS) |   GHS06,GHS09 |
| Signal word | Danger |
| Hazard statements | H301-H315-H319-H335-H400 |
| Precautionary statements | P261-P273-P301+P310-P305+P351+P338 |
| Hazard Codes | T,N |
| Risk Statements | 25-36/37/38-50/53 |
| Safety Statements | 26-45-60-61 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| HS Code | 2933491090 |
