Methyl Diethylphosphonoacetate , >96.0%(GC) , 1067-74-9

Synonym(s):
(Methoxycarbonylmethyl) diethoxyphosphine oxide;[(Methoxycarbonyl)methyl]phosphonic acid diethyl ester;Methyl P,P-diethylphosphonoacetate;NSC 147757

CAS NO.：1067-74-9

Empirical Formula: C7H15O5P

Molecular Weight: 210.16

MDL number: MFCD00009081

EINECS: 213-938-2

PRODUCT Properties

• Boiling point: 127-131 °C9 mm Hg(lit.)
• Density: 1.145 g/mL at 25 °C(lit.)
• refractive index: n20/D 1.433(lit.)
• Flash point: >230 °F
• storage temp.: Sealed in dry,Room Temperature
• solubility: Miscible with tetrahydrofuran.
• form: Liquid
• color: Clear colorless to faint yellow
• BRN: 1782397
• InChI: InChI=1S/C7H15O5P/c1-4-11-13(9,12-5-2)6-7(8)10-3/h4-6H2,1-3H3
• InChIKey: CTSAXXHOGZNKJR-UHFFFAOYSA-N
• SMILES: C(OC)(=O)CP(OCC)(OCC)=O
• CAS DataBase Reference: 1067-74-9(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, phosphono-, p,p-diethyl c-methyl ester(1067-74-9)

Description and Uses

Methyl diethylphosphonoacetate is used as a reagent in the preparation of allylic fluorides compounds and in regioselective Diels-Alder reactions. It also serves as a reactant in the preparation of substituted thiophenes and furans, which finds application in type 2 diabetes treatment. Further, it acts as a precursor in the synthesis of pyridone alkaloids and immunosuppressive cyclopentanediol derivatives. In addition to this, it is utilized in the modification of botulinum neurotoxin serotype A protease inhibitors.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313
• PPE: Eyeshields, Gloves, type ABEK (EN14387) respirator filter
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 10
• HS Code: 29310095
• Storage Class: 10 - Combustible liquids
• Hazard Classifications: Eye Irrit. 2; Skin Irrit. 2