N<SUB>3</SUB>-PEG<SUB>6</SUB>-CH<SUB>2</SUB>CH<SUB>2</SUB>COO<SUP>t</SUP>Bu , 97% , 406213-76-1

CAS NO.：406213-76-1

Empirical Formula: C19H37N3O8

Molecular Weight: 435.512

MDL number: MFCD20926385

PRODUCT Properties

• storage temp.: Storage temp. 2-8°C
• solubility: Soluble in Water, DMSO, DCM, DMF
• form: Liquid
• color: Colorless to light yellow
• InChI: InChI=1S/C19H37N3O8/c1-19(2,3)30-18(23)4-6-24-8-10-26-12-14-28-16-17-29-15-13-27-11-9-25-7-5-21-22-20/h4-17H2,1-3H3
• InChIKey: HRNUWAOLFSWRDG-UHFFFAOYSA-N
• SMILES: C(OC(C)(C)C)(=O)CCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]

Description and Uses

Azido-PEG6-t-butyl ester is a PEG molecule consisting of an azide group and a t-butyl ester moiety. he azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The hydrophilic PEG5 spacer increases solubility in aqueous media.

Azido-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG6-C2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.