BKM120 , ≥99% , 944396-07-0
CAS NO.：944396-07-0
Empirical Formula: C18H21F3N6O2
Molecular Weight: 410.39
MDL number: MFCD18251596
| Pack Size | Price | Stock | Quantity |
| 5MG | RMB511.20 | In Stock |
|
| 10MG | RMB910.40 | In Stock |
|
| 50MG | RMB1759.20 | In Stock |
|
| 250mg | RMB6687.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 143-147°C |
| Boiling point: | 645.7±65.0 °C(Predicted) |
| Density | 1.382 |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (15 mg/ml) |
| form | White powder. |
| pka | 5.94±0.50(Predicted) |
| color | White |
| Stability: | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
Description and Uses
Buparlisib (944396-07-0) is potent pan-Class I PI3-kinase inhibitor (IC50’s: p110α = 52 nM, p110 = 166 nM, p110δ = 116 nM. P110g = 262 nM).1,2 It inhibited microtubule dynamics at in vitro concentrations >1μM and doses above 50mg/kg in mice.3 Buparlisib lead to a precipitous drop in DNA synthesis in a mouse model of BRCA1-linked triple-negative breast cancer with less affect in normal tissue.4
NVP-BKM 120 is a novel anti-tumor active compound that is selective in that it inhibits specifically PI3 kinase activating cell death in glioma cells. Glioma cells being those that proliferate from tumors in the brain or the spine.
Safety
| Symbol(GHS) |   GHS08,GHS06 |
| Signal word | Danger |
| Hazard statements | H372-H341-H301 |
| Precautionary statements | P260-P264-P270-P314-P501-P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501 |
| HS Code | 29349990 |
