Phenformin hydrochloride , 97% , 834-28-6

Synonym(s):
N-(2-Phenylethyl)imidodicarbonimidic diamide monohydrochloride;Phenethylbiguanide;Phenformin hydrochloride

CAS NO.：834-28-6

Empirical Formula: C10H16ClN5

Molecular Weight: 241.72

MDL number: MFCD00035039

EINECS: 212-637-3

PRODUCT Properties

• Melting point: 175-178°C
• storage temp.: Keep in dark place,Inert atmosphere,2-8°C
• solubility: Methanol (Slightly), Water (Slightly)
• form: Solid
• color: White to Off-White
• Water Solubility: >=10 g/100 mL at 21 ºC
• InChI: InChI=1S/C10H15N5.ClH/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8;/h1-5H,6-7H2,(H6,11,12,13,14,15);1H
• InChIKey: YSUCWSWKRIOILX-UHFFFAOYSA-N
• SMILES: N=C(NCCC1C=CC=CC=1)NC(=N)N.[H]Cl
• CAS DataBase Reference: 834-28-6(CAS DataBase Reference)
• EPA Substance Registry System: Phenformin hydrochloride (834-28-6)

Description and Uses

Phenformin is an orally administered biguanide derivative with potential to lower blood glucose concentrations in patients with non-insulin-dependent diabetes mellitus. In general, biguanides improve insulin sensitivity and decrease insulin resistance by inhibiting complex 1 of the mitochondrial respiratory chain and inducing AMP-activated protein kinase (AMPK)-dependent signaling. Phenformin, however, has been withdrawn from clinical use because it also inhibits peripheral glucose oxidation and has an associated effect of inducing lactic acidosis when not metabolized sufficiently. Through AMPK activation, phenformin at 300 mg/kg exhibits anticancer activity by inhibiting the growth of MCF-7 and MDAMB231 breast cancer cell xenografts in mice.

It is an anti-diabetic drug from the biguanide class.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P280-P305+P351+P338
• Hazard Codes: Xn
• Risk Statements: 22
• Safety Statements: 36
• WGK Germany: 3
• RTECS: DU2200000
• HS Code: 29252900
• Toxicity: LD50 in mice (mg/kg): 19 i.v., 450 orally; in rats: 1050 orally; in guinea pigs: 47 orally, 19 s.c. (Proske)