PCI-34051 , ≥98% , 950762-95-5

CAS NO.：950762-95-5

Empirical Formula: C17H16N2O3

Molecular Weight: 296.32

MDL number: MFCD11114393

PRODUCT Properties

• Density: 1.25
• storage temp.: Sealed in dry,Store in freezer, under -20°C
• solubility: insoluble in H2O; insoluble in EtOH; ≥14.8 mg/mL in DMSO
• form: Powder
• pka: 9.16±0.30(Predicted)
• color: White to gray
• InChI: InChI=1S/C17H16N2O3/c1-22-15-6-2-12(3-7-15)11-19-9-8-13-4-5-14(10-16(13)19)17(20)18-21/h2-10,21H,11H2,1H3,(H,18,20)
• InChIKey: AJRGHIGYPXNABY-UHFFFAOYSA-N
• SMILES: N1(CC2=CC=C(OC)C=C2)C2=C(C=CC(C(NO)=O)=C2)C=C1

Description and Uses

PCI-34051 is a potent, histone deacetylase 8 (HDAC8)-specific inhibitor. PCI-34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias. PCI-34051 did not affect other hematopoietic or solid tumor lines. PCI-34051 treatment has been shown to significantly reduce cholesterol accumulation in Niemann-Pick type C1 gene mutated human fibroblast.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H319
• Precautionary statements: P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P
• Hazard Codes: Xn
• Risk Statements: 22-36
• Safety Statements: 26