BenzydamineHCl , 10mMinDMSO , 132-69-4

Synonym(s):
1-Benzyl-3-(3-[dimethylamino]propoxy)-1H-indazole

CAS NO.：132-69-4

Empirical Formula: C19H23N3O.ClH

Molecular Weight: 345.87

MDL number: MFCD00078957

EINECS: 205-076-0

PRODUCT Properties

• Melting point: 147-153°C
• storage temp.: Inert atmosphere,2-8°C
• solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• form: Solid
• color: White to Off-White
• Water Solubility: Soluble in water, ethanol, chloroform, n-butanol or DMSO /n
• Merck: 14,1122
• InChI: InChI=1S/C19H23N3O.ClH/c1-21(2)13-8-14-23-19-17-11-6-7-12-18(17)22(20-19)15-16-9-4-3-5-10-16;/h3-7,9-12H,8,13-15H2,1-2H3;1H
• InChIKey: HNNIWKQLJSNAEQ-UHFFFAOYSA-N
• SMILES: C12C=CC=CC=1C(=NN2CC1C=CC=CC=1)OCCCN(C)C.Cl
• CAS DataBase Reference: 132-69-4(CAS DataBase Reference)

Description and Uses

Benzydamine hydrochloride is a non-steroidal antiinflammatory drug used both topically and systemically. It has been reported as a sensitizer and a photosensitizer and caused occupational contact dermatitis in a nurse.

Benzydamine hydrochloride is an anti-in-flammatory drug used extensively in Europe and recently introduced in Canada to help re duce painful mucositis. Benzydamine provides short-term topical anesthesia and extended pain relief apparently through its anti-inflammatory properties. Studies have shown it to be effective in a range of painful conditions, including aphthous ulceration, chemotherapy-induced mucositis, and radiation-induced mucositis.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H319
• Precautionary statements: P264-P270-P280-P301+P312-P305+P351+P338-P337+P313
• Hazard Codes: Xn
• Risk Statements: 20/21/22-36
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: NK7875000
• HS Code: 2933.99.8290
• Toxicity: LD50 in mice, rats (mg/kg): 110, 100 i.p.; 515, 1050 orally (Silvestrini)