A6993558
Cardamonin , 10mMinDMSO , 19309-14-9
Synonym(s):
(2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one;(8CI); Alpinetin chalcone;(E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one, Wnt Pathway Inhibitor VII, Cardamonin;(E)-2′,4′-Dihydroxy-6′-methoxy-chalcone;Wnt/β-catenin Inhibitor, Cardamonin - CAS 19309-14-9 - Calbiochem
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB159.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 199～200℃ |
| Boiling point: | 484.5±45.0 °C(Predicted) |
| Density | 1.282±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: ≥20mg/mL |
| pka | 7.00±0.40(Predicted) |
| form | powder |
| color | yellow |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 weeks. |
| InChI | InChI=1S/C16H14O4/c1-20-15-10-12(17)9-14(19)16(15)13(18)8-7-11-5-3-2-4-6-11/h2-10,17,19H,1H3/b8-7+ |
| InChIKey | NYSZJNUIVUBQMM-BQYQJAHWSA-N |
| SMILES | C(C1=C(OC)C=C(O)C=C1O)(=O)/C=C/C1=CC=CC=C1 |
Description and Uses
Cardamonin (19309-14-9) inhibits NF-κB activation via inhibition of IκBα degradation and phosphorylation, IκB kinase activation and NF-κB nuclear translocation.1,2 Cardamonin displays anti-inflammatory activity in various models.3?Cell permeable.
Cardamonin has been used as a glycogen synthase kinase 3 (GSK3) inhibitor to study its effects on β-catenin loss and gain-of-function in human preimplantation embryos.
