AM580 , 10mMinDMSO , 102121-60-8
Synonym(s):
4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carboxamido]benzoic acid
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB210.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 265-267℃ |
| Boiling point: | 485.24°C (rough estimate) |
| Density | 1.154 |
| refractive index | 1.5614 (estimate) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (20mg/ml) or ethanol (10mg/ml). |
| form | White to off-white solid. |
| pka | 4.28±0.10(Predicted) |
| color | Off-white |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
Description and Uses
AM-580 (102121-60-8) is a retinoic acid analog acting as a RARα agonist (Kd = 8 nM).1 Induces or blocks differentiation depending on cell type and environment.2,3 In combination with CHIR-99021 it induces differentiation of human induced pluripotent stem cells (iPSCs) into intermediate mesoderm (80% induction rate in 5 days) capable of forming kidney structures.4 AM-580 exhibits anti-angiogenic activity in vivo, and induces differentiation of acute promyelocytic leukemia cells.5,6
Retinoid derivative used for gene expression studies of leukemia-retinoic acid receptor (PHL-RAR) cell line differentiation. AM 580 inhibits tumor proliferation by reducing the level of RARγ and activates RAR β. This receptor increases the expression of disintegrin and metalloprotease.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501 |
| WGK Germany | 3 |
| RTECS | DH6834890 |
| HS Code | 2924.29.7790 |
