SKF-525A Hydrochloride , ≥95% , 62-68-0

Synonym(s):
α-Phenyl-α-propylbenzeneacetic acid 2-(diethylamino)ethyl ester;N,N-Diethylaminoethyl 2,2-diphenylvalerate;Proadifen;SKF-525A;SKF-525A, Hydrochloride - CAS 62-68-0 - Calbiochem

CAS NO.：62-68-0

Empirical Formula: C23H32ClNO2

Molecular Weight: 389.96

MDL number: MFCD00055151

EINECS: 688-917-8

PRODUCT Properties

• Melting point: 122-123°C
• storage temp.: Inert atmosphere,Store in freezer, under -20°C
• solubility: Soluble in DMSO (up to 20 mg/ml)
• form: White solid
• color: Lustrous crystals from Me2CO/pet ether
• Water Solubility: Soluble in methanol or water
• Stability: Store in Freezer
• Major Application: forensics and toxicology; pharmaceutical (small molecule)
• InChI: 1S/C23H31NO2.ClH/c1-4-17-23(20-13-9-7-10-14-20,21-15-11-8-12-16-21)22(25)26-19-18-24(5-2)6-3;/h7-16H,4-6,17-19H2,1-3H3;1H
• InChIKey: FHIKZROVIDCMJA-UHFFFAOYSA-N
• SMILES: Cl.CCCC(C(=O)OCCN(CC)CC)(c1ccccc1)c2ccccc2
• EPA Substance Registry System: Proadifen hydrochloride (62-68-0)

Description and Uses

SKF 525A is a widely used, nonspecific cytochrome P (CYP)450 inhibitor that demonstrates 100% inhibition of the various CYP450 isoforms at 1-100 μM. It therefore potentiates the effects of many different drugs by inhibiting their metabolism (IC₅₀ values in the μM range when tested using human liver microsomes). SKF 525A inhibits CYP450-dependent arachidonic acid conversion to active EET metabolites, antagonizing the recovery of functional calcium pools. It also acts as a noncompetitive inhibitor of acetylcholine nicotinic receptors (IC₅₀ = 19 μM in mouse skeletal muscle).

Cytochrome P-459 inhibitor; blocks glibenclamide-sensitive K+ channels; inhibits neuronal nitric oxide synthetase; stimulates endothelial cell prostacyclin while inhibiting platelet thromboxane synthesis

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312a-P330-P501a
• PPE: dust mask type N95 (US), Eyeshields, Gloves
• Hazard Codes: Xn
• Risk Statements: 22
• Safety Statements: 36-24/25
• WGK Germany: 3
• RTECS: YV7175000
• HS Code: 29221990
• Storage Class: 11 - Combustible Solids
• Toxicity: LD50 oral in rat: 2140mg/kg