A7581158
IPA-3 , 10mMinDMSO , 42521-82-4
Synonym(s):
1,1′-Disulfanediyldinaphthalen-2-ol;2,2ʹ-Dihydroxy-1,1ʹ-dinaphthyldisulfide, PAK Inhibitor III;p21-Activated Kinase Inhibitor III, IPA-3 - CAS 42521-82-4 - Calbiochem
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB559.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 172℃ |
| Boiling point: | 543.7±35.0 °C(Predicted) |
| Density | 1.46±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: >20mg/mL |
| form | Yellow solid |
| pka | 7.52±0.50(Predicted) |
| color | off-white to yellow |
| Water Solubility | Soluble in DMSO or ethanol. Insoluble in water. |
| Sensitive | Light Sensitive |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| InChI | 1S/C20H14O2S2/c21-17-11-9-13-5-1-3-7-15(13)19(17)23-24-20-16-8-4-2-6-14(16)10-12-18(20)22/h1-12,21-22H |
| InChIKey | RFAXLXKIAKIUDT-UHFFFAOYSA-N |
| SMILES | Oc1ccc2ccccc2c1SSc3c(O)ccc4ccccc34 |
| CAS DataBase Reference | 42521-82-4 |
Description and Uses
IPA-3 (42521-82-4) is a selective allosteric inhibitor of Group 1 p21-activated kinase (PAK1 IC50= 2.5 μM)1via covalent binding to the PAK1 regulatory domain preventing binding to the upstream activator Cdc422. IPA-3 has been shown to induce cell death in human leukemic cell lines3, significantly inhibit TGFβ1-induced prostate cell epithelial to mesenchymal transition4and inhibit the growth of liver cancer cells5.
Acts as an allosteric inhibitor of Pak1
Safety
| Symbol(GHS) |   GHS05,GHS09 |
| Signal word | Danger |
| Hazard statements | H318-H410 |
| Precautionary statements | P273-P280-P305+P351+P338-P501 |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi,N |
| Risk Statements | 41-50/53 |
| Safety Statements | 26-39-60-61 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| HazardClass | 9 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Aquatic Acute 1 Aquatic Chronic 1 Eye Dam. 1 |
