Oroticacid , 10mMinDMSO , 65-86-1
Synonym(s):
2,6-Dihydroxypyrimidine-4-carboxylic acid;6-Carboxy-2,4-dihydroxypyrimidine;6-Carboxyuracil;Uracil-6-carboxylic acid
CAS NO.：65-86-1
Empirical Formula: C5H4N2O4
Molecular Weight: 156.1
MDL number: MFCD00006027
EINECS: 200-619-8
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB159.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | ≥300 °C |
| Boiling point: | 280.29°C (rough estimate) |
| Density | 1.6814 (rough estimate) |
| refractive index | 1.4800 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO : 32 mg/mL (205.00 mM; Need ultrasonic and warming) |
| pka | pK1:1.8(+1);pK2:9.55(0) (25°C) |
| form | Crystalline Powder |
| color | White |
| Water Solubility | Slightly soluble |
| Merck | 13,6942 |
| BRN | 383901 |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
| Cosmetics Ingredients Functions | SKIN CONDITIONING |
| InChI | 1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11) |
| InChIKey | PXQPEWDEAKTCGB-UHFFFAOYSA-N |
| SMILES | OC(=O)C1=CC(=O)NC(=O)N1 |
| LogP | -0.830 |
| CAS DataBase Reference | 65-86-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Orotic acid(65-86-1) |
| EPA Substance Registry System | Orotic acid (65-86-1) |
Description and Uses
Orotic acid is an intermediate in de novo pyrimidine biosynthesis that may be used to study the specificity and kinetics of orotate phosphoribosyltransferase (OPRT) which catalyzes the reversible phosphoribosyl transfer from 5-phospho-α-d-ribose 1-diphosphate (PRPP) to orotic acid (OA), forming pyrophosphate and orotidine 5-monophosphate (OMP). It is used as a starting material for the potential commercial bioproduction of uridine 5-monophosphate (UMP) by microbes such as Corynebacterium ammoniagenes (ATCC 6872) or Saccharomyces cerevisiae. It may be used to study the AMPK/SREBP-1 dependent cell signaling pathway and transcription regulation mechanisms that induce hepatic lipogenesis.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P301+P312+P330-P302+P352-P305+P351+P338 |
| target organs | Respiratory system |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26-36/37/39-22-37/39 |
| WGK Germany | 3 |
| RTECS | RM3180000 |
| F | 10-21 |
| Hazard Note | Harmful |
| TSCA | TSCA listed |
| HS Code | 29335990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
| Hazardous Substances Data | 65-86-1(Hazardous Substances Data) |
| Toxicity | pic-esc 1 g/L ZAPOAK12,583,72 |
