TBTU , 98% , 125700-67-6

Synonym(s):
N,N,N′,N′-Tetramethyl-O-(benzotriazol-1-yl)uronium tetrafluoroborate;2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate;TBTU

CAS NO.：125700-67-6

Empirical Formula: C11H16N5O.BF4

Molecular Weight: 321.08

MDL number: MFCD00077413

EINECS: 423-040-4

PRODUCT Properties

• Melting point: 205 °C (dec.)(lit.)
• storage temp.: 2-8°C
• solubility: acetonitrile: 0.1 g/mL, clear
• form: Powder
• color: White to Almost white
• Water Solubility: Soluble in acetonitrile (100 mg/ml, clear, colorless), DMF (160.55 mg/ml, clear), and water (3 mg/ml at 20°C).
• Sensitive: Moisture Sensitive
• BRN: 7066325
• InChI: InChI=1S/C11H16N5O.BF4/c1-13(2)11(14(3)4)15-9-7-5-6-8-10(9)16(17)12-15;2-1(3,4)5/h5-8H,1-4H3;/q+1;-1
• InChIKey: NQGZJNPFMLJDKU-UHFFFAOYSA-M
• SMILES: [B+3]([F-])([F-])([F-])[F-].C(=[N+]1/N=N(=O)C2=CC=CC=C/12)(\N(C)C)/N(C)C
• LogP: -2.65 at 21℃
• CAS DataBase Reference: 125700-67-6(CAS DataBase Reference)
• EPA Substance Registry System: 1H-Benzotriazolium, 1-[bis(dimethylamino)methylene]-, 3-oxide, tetrafluoroborate(1-) (1:1) (125700-67-6)

Description and Uses

TBTU is a coupling reagent for peptide synthesis causing low racemization, which is ideally suited for solid-phase peptide synthesis. Also used in the synthesis of acid based t-antigen glycodendrimers.

Safety

• Symbol(GHS): GHS02,GHS07
• Signal word: Danger
• Hazard statements: H228-H315-H319-H335
• Precautionary statements: P210-P240-P241-P261-P302+P352-P305+P351+P338
• Hazard Codes: Xi,F,E
• Risk Statements: 36/37/38-5-2
• Safety Statements: 26-36-37/39-36/37/39-35
• RIDADR: 1325
• WGK Germany: 3
• F: 8-10-21
• Hazard Note: Irritant/Flammable
• HS Code: 2933 99 80
• HazardClass: 4.1
• PackingGroup: Ⅱ