ProflavineHemisulfate , 10mMinWater , 1811-28-5
Synonym(s):
3,6-Diaminoacridine hemisulfate salt
CAS NO.：1811-28-5
Empirical Formula: C26H24N6O4S
Molecular Weight: 516.57
MDL number: MFCD00013150
EINECS: 217-320-3
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB159.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMSO (Slightly, Heated), Water (Slightly, Heated) |
| form | powder |
| color | Orange to Amber to Dark red |
| PH | pH (1g/l, 25℃) : 4.0～8.0 |
| Water Solubility | H2O: 10mg/mL |
| BRN | 3921806 |
| Stability: | Hygroscopic |
| Major Application | diagnostic assay manufacturing hematology histology |
| InChI | 1S/2C13H11N3.H2O4S.H2O/c2*14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10;1-5(2,3)4;/h2*1-7H,14-15H2;(H2,1,2,3,4);1H2 |
| InChIKey | DTRLDKDFCPUGCA-UHFFFAOYSA-N |
| SMILES | [H]O[H].OS(O)(=O)=O.Nc1ccc2cc3ccc(N)cc3nc2c1.Nc4ccc5cc6ccc(N)cc6nc5c4 |
| EPA Substance Registry System | 3,6-Acridinediamine, sulfate (2:1) (1811-28-5) |
Description and Uses
Proflavine Hemisulfate, the hemisulfate form of proflavin, is an acridine-derived fluorescent contrast agent and disinfectant used for cell imaging and antiseptic purposes. Following topical application, proflavin diffuses into cells and intercalates into DNA, leading to its accumulation in and staining of the nucleus. This allows visualization of the nucleus during fluorescence imaging. Such capability enables nuclear morphometry and facilitates the identification of cancer cells. Additionally, proflavin sulfate exerts antimicrobial effects through binding to bacterial DNA, which disrupts DNA synthesis and inhibits bacterial cell growth.
An Acridine derivative with limited antifungal activity
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 |
| target organs | Respiratory system |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | AR9065100 |
| F | 3-8-10-23 |
| TSCA | TSCA listed |
| HS Code | 2918.19.9000 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
| Toxicity | mouse,LD50,subcutaneous,200mg/kg (200mg/kg),Quarterly Journal of Pharmacy & Pharmacology. Vol. 10, Pg. 649, 1937. |
