α-Estradiol , 10mMinDMSO , 57-91-0

Synonym(s):
1,3,5(10)-Estratriene-3,17α-diol;3,17α-Dihydroxy-1,3,5(10)-estratriene;Epiestradiol

CAS NO.：57-91-0

Empirical Formula: C18H24O2

Molecular Weight: 272.39

MDL number: MFCD00064144

EINECS: 200-354-8

PRODUCT Properties

• Melting point: 176-180 °C(lit.)
• Boiling point: 355.44°C (rough estimate)
• alpha: D20 +53 to +56° (c = 0.9 in dioxane)
• Density: 1.0708 (rough estimate)
• refractive index: 1.4800 (estimate)
• storage temp.: Sealed in dry,Room Temperature
• solubility: ethanol: 50 mg/mL, clear, colorless
• form: powder
• pka: 10.27±0.60(Predicted)
• color: white with slight yellow
• biological source: synthetic (organic)
• Water Solubility: 3.9mg/L(25 ºC)
• Merck: 14,3704
• CAS DataBase Reference: 57-91-0(CAS DataBase Reference)
• NIST Chemistry Reference: Estra-1,3,5(10)-triene-3,17alpha-diol(57-91-0)
• EPA Substance Registry System: Estra-1,3,5(10)-triene-3,17-diol, (17.alpha.)- (57-91-0)

Description and Uses

Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17-Εstradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer’s disease and ischemic stroke.

Safety

• Symbol(GHS): GHS08,GHS09
• Signal word: Danger
• Hazard statements: H341-H351-H360F-H362-H410
• Precautionary statements: P201-P202-P260-P263-P273-P308+P313
• Hazard Codes: T,Xn
• Risk Statements: 45-48-40
• Safety Statements: 53-45-24/25-22
• RIDADR: UN 2811 6.1/PG 2
• WGK Germany: 3
• RTECS: KG3750000
• F: 8-10
• HS Code: 29372390