Tilorone dihydrochloride , 98% , 27591-69-1

Synonym(s):
2,7-Bis[2-(diethylamino)ethoxy]-9-fluorenone dihydrochloride

CAS NO.：27591-69-1

Empirical Formula: C25H36Cl2N2O3

Molecular Weight: 483.47

MDL number: MFCD00134071

PRODUCT Properties

• Melting point: 230-233 °C(lit.)
• storage temp.: Sealed in dry,Room Temperature
• solubility: Methanol (Slightly)
• form: Solid
• color: Orange
• Merck: 14,9440
• InChI: InChI=1S/C25H34N2O3.2ClH/c1-5-26(6-2)13-15-29-19-9-11-21-22-12-10-20(30-16-14-27(7-3)8-4)18-24(22)25(28)23(21)17-19;;/h9-12,17-18H,5-8,13-16H2,1-4H3;2*1H
• InChIKey: BSVYJQAWONIOOU-UHFFFAOYSA-N
• SMILES: C12C=CC(OCCN(CC)CC)=CC=1C(=O)C1C=C(OCCN(CC)CC)C=CC2=1.Cl.Cl
• CAS DataBase Reference: 27591-69-1(CAS DataBase Reference)

Description and Uses

Tilorone is an orally active, antiviral compound that induces interferon production and is reported to have antitumor, anti-inflammatory, and neuroprotective actions. With chronic administration, tilorone induces lysosomal glycosaminoglycan storage, rendering glycosaminoglycans resistant to enzymatic degradation.

Tilorone dihydrochloride was used to study the interaction of drugs with synthetic self-complementary DNA by SPR (Surface Plasmon Resonance).

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Warning
• Hazard statements: H302+H312+H332-H315-H319-H335-H351
• Precautionary statements: P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338-P308+P313
• target organs: Respiratory system
• PPE: dust mask type N95 (US), Eyeshields, Gloves
• Hazard Codes: Xn
• Risk Statements: 20/21/22-36/37/38-40
• Safety Statements: 7-22-26-37/39
• WGK Germany: 3
• RTECS: LL9000000
• HS Code: 2922.39.4500
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Acute Tox. 4 Dermal; Acute Tox. 4 Inhalation; Acute Tox. 4 Oral; Carc. 2; Eye Irrit. 2; Skin Irrit. 2; STOT SE 3
• Toxicity: LD50 in mice, rats (single dose): 959, 852 mg/kg orally; 145, 244 mg/kg i.p. (Krueger, Mayer)