A7788258
Meclizine2HCl , 2mMinDMSO , 1104-22-9
Synonym(s):
1-([4-Chlorophenyl]phenylmethyl)-4-([3-methylphenyl]methyl)piperazine;1-(p-Chloro-α-phenylbenzyl)-4-(m-methylbenzyl)-piperazine dihydrochloride;1-[(4-Chlorophenyl)phenylmethyl]4-[?(3-methylphenyl)methyl]piperazine dihydrochloride;Meclizine dihydrochloride;NSC 28728
CAS NO.：1104-22-9
Empirical Formula: C25H29Cl3N2
Molecular Weight: 463.87
MDL number: MFCD00058199
EINECS: 214-164-8
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB559.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 210.0 to 214.0 °C |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble5mg/mL, clear (warmed) |
| form | powder |
| color | white to beige |
| CAS DataBase Reference | 1104-22-9(CAS DataBase Reference) |
| EPA Substance Registry System | Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, dihydrochloride (1104-22-9) |
Description and Uses
Meclizine is a histamine H1 receptor antagonist (Ki = 250 nM). Pretreatment with meclizine (2.5-30 mg/kg, i.p.) reduces ovalbumin-induced mast cell degranulation, edema, and leukocyte influx in rat lung. Formulations containing meclizine have been used in the treatment of motion sickness and vertigo.
Meclizine Dihydrochloride is a histamine H1 receptor antagonist with antiemetic properties. Meclizine Dihydrochloride is a research product for neuroscience. This compound may exhibit neuroprotective properties.
Safety
| Symbol(GHS) |   GHS07,GHS08 |
| Signal word | Warning |
| Hazard statements | H302-H361 |
| Precautionary statements | P201-P301+P312+P330-P308+P313 |
| Hazard Codes | Xn |
| Risk Statements | 22-63 |
| Safety Statements | 22-36 |
| WGK Germany | 3 |
| RTECS | TL2005000 |
| HS Code | 2933.59.8000 |
| Toxicity | LD50 oral in mouse: 1600mg/kg |
