Tolnaftate , ≥98% , 2398-96-1
Synonym(s):
Methyl-(3-methylphenyl)carbamothioic acid O-2-naphthyl ester;Tolnaftate
CAS NO.：2398-96-1
Empirical Formula: C19H17NOS
Molecular Weight: 307.41
MDL number: MFCD00056611
EINECS: 219-266-6
| Pack Size | Price | Stock | Quantity |
| 1G | RMB44.00 | In Stock |
|
| 5G | RMB87.20 | In Stock |
|
| 25G | RMB308.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 110.5-111.5°C |
| Boiling point: | 453.4±38.0 °C(Predicted) |
| Density | 1.1328 (rough estimate) |
| refractive index | 1.6970 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Soluble in chloroform at 50 mg/ml. Sparingly soluble in ethanol or methanol |
| form | powder |
| pka | -0.35±0.50(Predicted) |
| color | white to off-white |
| Water Solubility | <0.1 g/100 mL at 22 ºC |
| λmax | 258nm(MeOH)(lit.) |
| Merck | 14,9519 |
| Major Application | pharmaceutical (small molecule) |
| Cosmetics Ingredients Functions | ANTIMICROBIAL |
| InChI | 1S/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H,1-2H3 |
| InChIKey | FUSNMLFNXJSCDI-UHFFFAOYSA-N |
| SMILES | CN(C(=S)Oc1ccc2ccccc2c1)c3cccc(C)c3 |
| LogP | 5.142 (est) |
| NIST Chemistry Reference | Tolnaftate(2398-96-1) |
| EPA Substance Registry System | Tolnaftate (2398-96-1) |
Description and Uses
Tolnaftate is a thiocarbamate antifungal agent. It is active against clinical isolates of the dermatophytes T. rubrum, T. mentagraphytes, T. verrucosum, E. floccosum, and M. canis (MIC50s = 50, 100, 6, 50, and 50 ng/ml, respectively), as well as 18 additional yeast and filamentous fungi species (MIC = 0.003-0.8 μg/ml)., Tolnaftate also reduces aflatoxin production in A. parasiticus in a concentration-dependent manner. It inhibits squalene epoxidase with an IC50 value of 12.5 μg/ml in a cell-free assay.
Tolnaftate topical is used to treat skin infections such as athlete's foot, jock itch, and ringworm infections. Tolnaftate is also used, along with other antifungals, to treat infections of the nails, scalp, palms, and soles of the feet.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | 2 |
| RTECS | FD8891300 |
| TSCA | TSCA listed |
| HazardClass | IRRITANT |
| HS Code | 2930206050 |
| Storage Class | 11 - Combustible Solids |
| Toxicity | LD50 in mice, rats (g/kg): >10, >6 orally; >6, >4 s.c. (Hashimoto) |
