Tetraethyl methylenediphosphonate , ≥98% , 1660-94-2

Synonym(s):
Bis(diethoxyphosphinyl)methane;Methylenediphosphonic acid tetraethylester;NSC 133889

Update time: 2022-07-08

Boiling point:	171-174 °C11 mm Hg(lit.)
Density	1.16 g/mL at 25 °C(lit.)
refractive index	n20/D 1.442(lit.)
Flash point:	>230 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Sparingly), Methanol (Slightly)
form	Liquid
Specific Gravity	1.160
color	Clear yellow to yellow-brown
Water Solubility	Slightly miscible with water.
BRN	1813241
InChI	InChI=1S/C9H22O6P2/c1-5-12-16(10,13-6-2)9-17(11,14-7-3)15-8-4/h5-9H2,1-4H3
InChIKey	STJWVOQLJPNAQL-UHFFFAOYSA-N
SMILES	C(P(=O)(OCC)OCC)P(=O)(OCC)OCC
CAS DataBase Reference	1660-94-2(CAS DataBase Reference)
EPA Substance Registry System	Phosphonic acid, methylenebis-, tetraethyl ester (1660-94-2)

Reactant for synthesis of:

Dual substrate-site inhibitors of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
Unnatural alpha-amino acid derivatives containing gem-biphosphonates
Biphenyl sulfonylamino Me bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption
Lycopene via Wittig-Horner reaction
Alkylaminoethylbisphosphinic acids to target farnesyl diphosphate synthase
Aromatic bisphosphonates for use as inhibitors of geranylgeranyl diphosphate synthase

Precursor for synthesis of dendritic polyglycerol anions used toward L-selectin inhibition

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P280g-P305+P351+P338
Hazard Codes	Xi,C
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
RTECS	SZ9150000
Hazard Note	Corrosive
TSCA	Yes
HS Code	29319090
Toxicity	mouse,LD50,intravenous,180mg/kg (180mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03139,