Uridine 5'-diphosphate disodium salt hydrate , ≥96.0%(HPLC) , 27821-45-0

CAS NO.：27821-45-0

Empirical Formula: C15H24N2Na2O18P2

Molecular Weight: 628.28

MDL number: MFCD00084679

EINECS: 248-678-9

PRODUCT Properties

• storage temp.: -20°C
• form: Powder
• color: White to Off-white
• biological source: synthetic
• Water Solubility: Slightly soluble in water.
• Sensitive: Moisture Sensitive
• BRN: 8817400
• InChIKey: KWDGQJWFEYTPBN-IBOJMDDDSA-L
• SMILES: O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]1N1C=CC(=O)NC1=O)O.[NaH] |&1:1,2,3,15,r|
• CAS DataBase Reference: 27821-45-0(CAS DataBase Reference)

Description and Uses

Uridine-5'-diphosphate disodium salt (UDP-Na2) is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52 for human P2Y6 receptor). It is an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis. It has also been used as a purinergic agonist, in order to study its effect on the flux of absorbed cations in cochlear outer sulcus cells (OSC) and vestibular migratory cells (VTC). UDP-Na2 has also been used to determine the activity of nucleoside diphosphatase (NDPase) in the rabbit retina.

Uridine-5'-diphosphate disodium salt is mainly used in nucleic acid (RNA) biosynthesis and cell signalling studies. Uridine-5'-monophosphate disodium salt (UDP-MS) is a structural analogue of uridine and is used as a dietary supplement. It has been shown to inhibit phosphodiesterase and cyclic nucleotide phosphodiesterase, both of which are enzymes that degrade the secondary messenger cyclic adenosine monophosphate (cAMP).

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 10-21
• HS Code: 29349990