N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide , 95% , 302964-08-5

CAS NO.：302964-08-5

Empirical Formula: C16H13Cl2N5OS

Molecular Weight: 394.28

MDL number: MFCD11045075

EINECS: 695-686-7

PRODUCT Properties

• Melting point: 333-335°C
• Boiling point: 566.95° C (Predicted)
• Density: 1.516±0.06 g/cm3(Predicted)
• refractive index: n20D 1.72 (Predicted)
• storage temp.: Inert atmosphere,2-8°C
• solubility: DMSO (Slightly)
• pka: 10.92±0.70(Predicted)
• form: Solid
• color: Pale Yellow
• Water Solubility: Slightly soluble in water
• InChI: InChI=1S/C16H13Cl2N5OS/c1-8-4-3-5-10(17)14(8)23-15(24)11-7-19-16(25-11)22-13-6-12(18)20-9(2)21-13/h3-7H,1-2H3,(H,23,24)(H,19,20,21,22)
• InChIKey: LMXUWARKUIELGT-UHFFFAOYSA-N
• SMILES: S1C(C(NC2=C(C)C=CC=C2Cl)=O)=CN=C1NC1C=C(Cl)N=C(C)N=1
• CAS DataBase Reference: 302964-08-5(CAS DataBase Reference)

Description and Uses

N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide is a pharmaceutical intermediate compound used as a synthetic intermediate for dasatinib. Dasatinib is a targeted anticancer drug used to treat chronic myeloid leukaemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukaemia (ALL). It is also a receptor and non-receptor Tyk (tyrosine kinase) inhibitor, which plays an important role in certain cancers and fibrotic diseases.

Dasatinib intermediate. A protein tyrosine kinase inhibitor.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319
• Precautionary statements: P261-P305+P351+P338
• HS Code: 2933399990