Hexamethylphosphoramide , 98% , 680-31-9

Synonym(s):
Hexamethylphosphoric acid triamide;HMPA;Tris(dimethylamino)phosphine oxide

CAS NO.：680-31-9

Empirical Formula: C6H18N3OP

Molecular Weight: 179.2

MDL number: MFCD00008303

EINECS: 211-653-8

PRODUCT Properties

• Melting point: 7 °C (lit.)
• Boiling point: 230-232 °C/740 mmHg (lit.)
• Density: 1.03 g/mL at 25 °C (lit.)
• vapor density: 6.18 (vs air)
• vapor pressure: 0.07 mm Hg ( 25 °C)
• refractive index: n20/D 1.459(lit.)
• Flash point: 222 °F
• storage temp.: Inert atmosphere,Room Temperature
• solubility: Chloroform (Soluble), Methanol (Slightly)
• pka: 4.69±0.70(Predicted)
• form: liquid
• color: Colorless to light yellow liquid
• Odor: Spicy odor (no threshold data)
• Water Solubility: Miscible
• FreezingPoint: 7℃
• Merck: 14,4725
• BRN: 1099903
• Dielectric constant: 30.0（20℃）
• Stability: Stable. Incompatible with strong acids, strong oxidizing agents.
• InChIKey: GNOIPBMMFNIUFM-UHFFFAOYSA-N
• CAS DataBase Reference: 680-31-9(CAS DataBase Reference)
• IARC: 2B (Vol. 15, Sup 7, 71) 1999
• NIST Chemistry Reference: N,N,N',N',N",N'-Hexamethylphosphorotriamide(680-31-9)
• EPA Substance Registry System: Hexamethylphosphoramide (680-31-9)

Description and Uses

Hexamethylphosphoric triamide is a colorlessliquid with a spicy odor. Molecular weight = 179.24; .Specific gravity (H2O:1l)= 1.03; Boiling point= 232.8℃;FreezingMelting point = 6.1℃; Relative vapor density(air= 1)=6.18; V apor pressure = 0.03 mmHg at 20℃;Flash point= 104.4℃. Hazard Identification (basedonNFPA-704 M Rating System): Health 2, Flammability 1,Reactivity 0. Soluble in water.

Hexamethylphosphoramide is a dipolar co-solvent and an effective additive used in reactions like reduction of halides, deoxygenation of sulfones, halide olefin couplings and cleavage of carbon-sulfur bond.

Safety

• Symbol(GHS): GHS05,GHS08
• Signal word: Danger
• Hazard statements: H314-H340-H350
• Precautionary statements: P202-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363
• Hazard Codes: T
• Risk Statements: 45-46
• Safety Statements: 53-45-99
• RIDADR: 2810
• WGK Germany: 3
• RTECS: TD0875000
• F: 8
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 29299090
• Hazardous Substances Data: 680-31-9(Hazardous Substances Data)
• Toxicity: LD50 in male, female rats (mg/kg): 2650, 3360 orally (Gaines)