Triclabendazole , 98% , 68786-66-3

Synonym(s):
5-Chloro-6-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole;Triclabendazole

CAS NO.：68786-66-3

Empirical Formula: C14H9Cl3N2OS

Molecular Weight: 359.66

MDL number: MFCD00864519

EINECS: 614-728-7

PRODUCT Properties

• Melting point: 175-176°C
• Boiling point: 240.6°C (rough estimate)
• Density: 1.3875 (rough estimate)
• refractive index: 1.6000 (estimate)
• storage temp.: Sealed in dry,Room Temperature
• solubility: Acetonitrile (Slightly, Sonicated), Methanol (Slightly)
• form: Solid
• pka: 7.91±0.10(Predicted)
• color: White to Beige
• Merck: 14,9652
• BCS Class: 4/3
• Stability: Stability
• InChI: InChI=1S/C14H9Cl3N2OS/c1-21-14-18-9-5-8(16)12(6-10(9)19-14)20-11-4-2-3-7(15)13(11)17/h2-6H,1H3,(H,18,19)
• InChIKey: NQPDXQQQCQDHHW-UHFFFAOYSA-N
• SMILES: C1(SC)NC2=CC(Cl)=C(OC3=CC=CC(Cl)=C3Cl)C=C2N=1
• CAS DataBase Reference: 68786-66-3(CAS DataBase Reference)

Description and Uses

Triclabendazole is a benzimidazole anthelmintic. It eliminates both immature and adult flukes in a sheep model of F. hepatica infection when administered at a dose of 10 mg/kg. Triclabendazole (5 μM) also protects against glucose- or α-synuclein-induced apoptosis in S. cerevisiae via inhibition of adenylyl cyclase in the Ras-adenylyl cyclase-protein kinase A (PKA) nutrient sensing pathway.

An anthelmintic (fasciola).

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36-24/25
• WGK Germany: 3
• RTECS: DD6747000
• HS Code: 29339900
• Toxicity: LD50 oral in rabbit: 206mg/kg