7-Chloroisoquinolin-1-ol , 97% , 24188-74-7

CAS NO.：24188-74-7

Empirical Formula: C9H6ClNO

Molecular Weight: 179.6

MDL number: MFCD08436984

PRODUCT Properties

• Melting point: 245-247 °C(Solv: methanol (67-56-1))
• Boiling point: 414.9±45.0 °C(Predicted)
• Density: 1.339±0.06 g/cm3(Predicted)
• storage temp.: Sealed in dry,Room Temperature
• pka: 11.99±0.20(Predicted)
• Appearance: Off-white to light yellow Solid
• InChI: InChI=1S/C9H6ClNO/c10-7-2-1-6-3-4-11-9(12)8(6)5-7/h1-5H,(H,11,12)
• InChIKey: YWUCOQGBXQHOJM-UHFFFAOYSA-N
• SMILES: C1(=O)C2=C(C=CC(Cl)=C2)C=CN1

Description and Uses

7-Chloroisoquinolin-1(2H)-one acts as a reagent for the preparation, SAR of methoxyisoquinoline derivative and discovery of asunaprevir (BMS-650032), an orally efficacious NS3 protease inhibitor for the treatment of hepatitis C virus infection. Synthesis and pharmacological evaluation of a series of 1,2-dihydro-1-[(5-methyl-1-imidazol-4-yl)methyl]-2-oxopyridine 5-HT3 antagonists.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H332-H335
• Precautionary statements: P280-P305+P351+P338-P310
• HS Code: 2933499090