BD1537848
(E)-5-(2-Bromovinyl)pyrimidine-2,4(1H,3H)-dione , 95%mixTBCasstabilizer , 69304-49-0
| Pack Size | Price | Stock | Quantity |
| 1g | RMB8320.00 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 189-194 °C (dec.)(lit.) |
| Density | 1.881 |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| pka | 7.54±0.10(Predicted) |
| form | Solid |
| color | Pale Beige to Beige |
| InChI | 1S/C6H5BrN2O2/c7-2-1-4-3-8-6(11)9-5(4)10/h1-3H,(H2,8,9,10,11)/b2-1+ |
| InChIKey | BLXGZIDBSXVMLU-OWOJBTEDSA-N |
| SMILES | Br\C=C\C1=CNC(=O)NC1=O |
Description and Uses
(E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner. It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil (HY-90006) in a P388 murine leukemia model when administered at a dose of 200 μmol/kg, increasing survival time.
Safety
| PPE | Eyeshields, Gloves, type N95 (US) |
| WGK Germany | 2 |
| RTECS | UV9020500 |
| Storage Class | 13 - Non Combustible Solids |
