PRODUCT Properties
| Melting point: | 164-165 °C |
| Boiling point: | 565.9±50.0 °C(Predicted) |
| Density | 1.291±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO : 50 mg/mL (143.11 mM; Need ultrasonic and warming) |
| form | Powder |
| pka | 2.36±0.20(Predicted) |
| color | White to off-white |
Description and Uses
Dihydrochelerythrine is a benzophenanthridine alkaloid that has been found in Bocconia arborea and has diverse biological activities. It is active against S. aureus, S. faecalis, and C. albicans (MIC = 1.87 μg/ml for all). Dihydrochelerythrine inhibits secretion of the hepatitis B virus (HBV) antigens HBsAg and HBeAg from HepG2 2.2.15 cells (IC50s = <0.05 μM for both). It is cytotoxic to HCT8, BGC-823, and A2780 cancer cells (IC50s = 1.4, 0.4, and 3.5 μM, respectively).
Dihydrochelerythrine is synthesized as a potential G-quadrulpex DNA stabilizing agent. It is used in phamacokinetic study of chelerythrine metabolites in agro-products.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H227 |
| Precautionary statements | P501-P210-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313-P403+P235 |
