3-Deazaadenosine , 99+% , 6736-58-9

Synonym(s):
4-Amino-1-(β-D-ribofuranosyl)-1H-imidazo(4,5)-pyridine

CAS NO.：6736-58-9

Empirical Formula: C11H14N4O4

Molecular Weight: 266.25

MDL number: MFCD00153951

PRODUCT Properties

• Melting point: 228-229°C
• Boiling point: 665.7±65.0 °C(Predicted)
• Density: 1.90±0.1 g/cm3 (20 ºC 760 Torr)
• storage temp.: Keep in dark place,Inert atmosphere,2-8°C
• solubility: H₂O: 10 mg/mL with heating to 60 °C
• form: Solid
• pka: 13.24±0.70(Predicted)
• color: White to Off-White
• InChI: 1S/C11H14N4O4/c12-10-7-5(1-2-13-10)15(4-14-7)11-9(18)8(17)6(3-16)19-11/h1-2,4,6,8-9,11,16-18H,3H2,(H2,12,13)/t6-,8-,9-,11-/m1/s1
• InChIKey: DBZQFUNLCALWDY-PNHWDRBUSA-N
• SMILES: Nc1nccc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O

Description and Uses

3-Deazaadenosine (3-DZA) is an inhibitor of SAH (Sadenosylhomocysteine) hydrolase (Ki = 3.9 μM). It has antiinflammatory properties, inhibiting leukocyte adhesion and chemotaxis, lymphocyte-mediated cytolysis, phagocytosis, degranulation, and NF-κB signaling. 3-DZA also has anti-viral and anti-bacterial activities.

Possesses antiviral activity. It is an inhibitor of leukocyte adhesion to TNF-treated endothelial cells.

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H302+H312-H315-H319-H331-H335
• Precautionary statements: P261-P280-P305+P351+P338-P311
• PPE: Eyeshields, Gloves, type N95 (US)
• Safety Statements: 24/25
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: 6.1(a)
• PackingGroup: II
• HS Code: 29419090
• Storage Class: 11 - Combustible Solids