7-Deaza-2'-dG , 97% , 86392-75-8

CAS NO.：86392-75-8

Empirical Formula: C11H14N4O4

Molecular Weight: 266.25

MDL number: MFCD00672278

EINECS: 500-100-4

PRODUCT Properties

• Melting point: 262-265 °C
• Density: 1.90±0.1 g/cm3(Predicted)
• storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
• pka: 11.29±0.20(Predicted)
• Appearance: White to off-white Solid
• Crystal Structure: Orthorhombic, colorless needles
• Space group: P2₁2₁2₁
• Lattice constant: a = 5.4146(12) Å, b = 10.969(2) Å, c = 19.968(4) Å, V = 1185.9(4) ų, Z = 4
• InChI: InChI=1/C11H14N4O4/c12-11-13-9-5(10(18)14-11)1-2-15(9)8-3-6(17)7(4-16)19-8/h1-2,6-8,16-17H,3-4H2,(H3,12,13,14,18)/t6-,7+,8+/s3
• InChIKey: PFCLMNDDPTZJHQ-JUCUSOLINA-N
• SMILES: N1(C=CC2C(=O)NC(N)=NC1=2)[C@H]1C[C@H](O)[C@@H](CO)O1 |&1:11,13,15,r|

Description and Uses

7-Deaza-2'-deoxyguanosine is one of the most widely used modified nucleosides in the fields of chemistry, molecular biology and nanotechnology. It is known for its applications in the form of its 5'-triphosphate in Sanger DNA sequencing. As 7-deaza-2'-deoxyguanosine cannot form dG-tetramers, band compression in gel electrophoresis is reduced. Furthermore, replacing 2′-deoxyguanosine with 7-deaza-2′-deoxyguanosine enhances the sensitivity of MALDI-TOF (matrix-assisted laser desorption time-of-flight) mass spectrometry analysis of DNA fragments^[1].