Piceatannol , 98% , 10083-24-6

Synonym(s):
(E)-4-[2-(3,5Dihydroxyphenyl)ethenyl]1,2-benzenediol;trans-3,3?,4,5?-Tetrahydroxystilbene;3,3′,4,5′-Stilbenetetrol;3,3′,4,5′-Tetrahydroxy-trans-stilbene;Astringenin

CAS NO.：10083-24-6

Empirical Formula: C14H12O4

Molecular Weight: 244.24

MDL number: MFCD00221715

EINECS: 600-132-4

PRODUCT Properties

• Melting point: 223.0-227.0 °C
• Boiling point: 108°C/0.04mmHg(lit.)
• Density: 1.1245 (rough estimate)
• refractive index: 1.5190 (estimate)
• storage temp.: 2-8°C
• solubility: H₂O: 0.5 mg/mL
• form: powder
• pka: 9.17±0.10(Predicted)
• color: light tan to yellow
• Water Solubility: H2O: 0.5mg/mL; DMSO: 10mg/mL; ethanol: 10mg/mL
• λmax: 323nm(MeOH)(lit.)
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
• InChI: InChI=1S/C14H12O4/c15-11-5-10(6-12(16)8-11)2-1-9-3-4-13(17)14(18)7-9/h1-8,15-18H/b2-1+
• InChIKey: CDRPUGZCRXZLFL-OWOJBTEDSA-N
• SMILES: C1(O)=CC=C(/C=C/C2=CC(O)=CC(O)=C2)C=C1O
• LogP: 2.690 (est)

Description and Uses

Piceatannol (10083-24-6) is a naturally occurring analog of resveratrol (Cat.# 10-1057). Inhibits nonreceptor kinases Syk and Lyk (IC50 approximately 10 μM).1 Piceatannol stimulates Sirt1.2

Piceatannol has been used:

• to study its effect on Ataxia-Telangiectasia Mutated (ATM) protein kinase
• as an inhibitor of ZAP-70 (ζ-chain-associated protein kinase 70)
• as an inhibitor of MRP1-mediated 2′,7′-bis-(carboxypropyl)-5(6)-carboxyfluorescein (BCPCF) transport in intact human erythrocytes and inside-out erythrocyte vesicles (IOVs)

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302+H312+H332
• Precautionary statements: P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312
• Safety Statements: 24/25
• WGK Germany: 3
• HS Code: 29072990