Pyridine-2,4-dicarboxylicacidhydrate , 98% , 207671-42-9

CAS NO.：207671-42-9

Empirical Formula: C7H7NO5

Molecular Weight: 185.13

MDL number: MFCD00149413

EINECS: 629-130-1

PRODUCT Properties

• Melting point: 246-248 °C (dec.)(lit.)
• storage temp.: Store at -20°C
• solubility: DMSO: 1.4 mg/ml; PBS (pH 7.2): 0.2 mg/ml
• form: A crystalline solid
• BRN: 131631
• InChI: 1S/C7H5NO4.H2O/c9-6(10)4-1-2-8-5(3-4)7(11)12;/h1-3H,(H,9,10)(H,11,12);1H2
• InChIKey: PLNFTNOXJDBMSM-UHFFFAOYSA-N
• SMILES: [H]O[H].OC(=O)c1ccnc(c1)C(O)=O

Description and Uses

2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is a compound that structurally mimics 2-oxoglutarate (2-OG, also known as α-ketoglutarate) and chelates zinc, thus affecting a range of enzymes. As a 2-OG mimic, it blocks the activity of 2-OG oxygenases, which include certain lysine demethylases and a variety of hydroxylases (e.g., prolyl, collagen, lysyl). 2,4-PDCA inhibits several Jumonji domain-containing lysine demethylases when used at low micromolar concentrations. Through its effects on hydroxylases, including prolyl hydroxlase 1 (IC₅₀ = 1.5 μM), 2,4-PDCA modulates hypoxia-inducible factor turnover, collagen synthesis, and plant cell wall formation. It can inhibit zinc-dependent enzymes, like metallo-β-lactamase. 2,4-PDCA also affects and is translocated by organic anion transporters.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P302+P352-P305+P351+P338
• target organs: Respiratory system
• PPE: dust mask type N95 (US), Eyeshields, Gloves
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Eye Irrit. 2; Skin Irrit. 2; STOT SE 3