LN-645316
R-(-)-Apomorphine , 99% , 41372-20-7
Synonym(s):
R-(−)-Apomorphine hydrochloride hemihydrate
Update time: 2023-04-23
PRODUCT Properties
| Melting point: | 285-287 °C(lit.) |
| alpha | -48 º (c=1, H2O) |
| storage temp. | Refrigerator |
| solubility | H2O: ~10 mg/mL, clear, yellow-green |
| form | Solid |
| color | white to gray |
| PH | pH(10g/l, 25℃) : 4.0～5.0 |
| Water Solubility | H2O: ~10mg/mL, clear, yellow-green |
| Merck | 13,751 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 week. |
| InChI | 1S/2C17H17NO2.2ClH.H2O/c2*1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12;;;/h2*2-6,13,19-20H,7-9H2,1H3;2*1H;1H2/t2*13-;;;/m11.../s1 |
| InChIKey | CXWQXGNFZLHLHQ-DPFCLETOSA-N |
| SMILES | Cl[H].Cl[H].[H]O[H].[H][C@]12Cc3ccc(O)c(O)c3-c4cccc(CCN1C)c24.[H][C@]56Cc7ccc(O)c(O)c7-c8cccc(CCN5C)c68 |
| CAS DataBase Reference | 41372-20-7(CAS DataBase Reference) |
Description and Uses
Apomorphine (41372-20-7) is an archetypal dopamine pan-receptor agonist. Displays anti-Parkinsons activity in vivo.1 Protects against MPTP-induced neurotoxicity in a mouse mode1,2 In clinical use for Parkinson’s disease.4,5
R-(?)-Apomorphine hydrochloride hemihydrate is a nonselective dopamine agonist with anti-Parkinsonian and neuroprotective effects in vivo.
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301+P330+P331+P310 |
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 36 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| HS Code | 2933997000 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral |
