BV6? , ≥99% , 1001600-56-1
CAS NO.：1001600-56-1
Empirical Formula: C70H96N10O8
Molecular Weight: 1205.57
MDL number: MFCD28168021
| Pack Size | Price | Stock | Quantity |
| 2mg | RMB551.20 | In Stock |
|
| 5mg | RMB758.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Boiling point: | 1376.7±65.0 °C(Predicted) |
| Density | 1.177±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | ≥60.28 mg/mL in DMSO; insoluble in H2O; ≥12.6 mg/mL in EtOH with ultrasonic |
| form | solid |
| pka | 12.89±0.20(Predicted) |
| color | White to off-white |
| InChIKey | DPXJXGNXKOVBJV-YLOPQIBLSA-N |
Description and Uses
BV6 is a bivalent Smac mimetic and an antagonist of the inhibitor of apoptosis (IAP) proteins that binds to IAP1 and XIAP (Kds = 0.46 and 1.3 nM, respectively). It induces autoubiquitination and proteasomal degradation of IAP1 and XIAP in MDA-MB-231 cells when used at a concentration of 5 μM. BV6 (4 μM) induces NF-κB activation and TNF-dependent apoptosis in A2058 and MDA-MB-231 cells. It enhances radiosensitization and increases apoptosis in HCC193 and H460 non-small cell lung cancer (NSCLC) cell lines. BV6 (1 μM) induces cell death in a panel of 40 primary, patient-derived B cell precursor acute lymphoblastic leukemia (BCP-ALL) samples in a TNF-dependent manner. In vivo, BV6 (10 mg/kg) increases survival and the time to relapse in a high-risk BCP-ALL patient-derived xenograft (PDX) mouse model.
BV-6 is a SMAC mimetic and inhibitor of apoptosis (IAP) inhibitor. Apoptosis agent.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
