LosartanCarboxaldehyde , 95% , 114798-36-6
Synonym(s):
2-Butyl-4-chloro-1-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde;2-Butyl-4-chloro-1-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-imidazole-5-carbaldehyde;EXP-3179
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB558.40 | In Stock |
|
| 25mg | RMB870.40 | In Stock |
|
| 100mg | RMB2630.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 84-86°C |
| Boiling point: | 666.7±65.0 °C(Predicted) |
| Density | 1.34±0.1 g/cm3(Predicted) |
| storage temp. | Refrigerator, Under Inert Atmosphere |
| solubility | Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 4.16±0.10(Predicted) |
| color | Off-White to Light Yellow |
| InChI | InChI=1S/C22H21ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,14H,2-3,8,13H2,1H3,(H,25,26,27,28) |
| InChIKey | FQZSMTSTFMNWQF-UHFFFAOYSA-N |
| SMILES | C1(CCCC)N(CC2=CC=C(C3=CC=CC=C3C3=NNN=N3)C=C2)C(C=O)=C(Cl)N=1 |
| CAS DataBase Reference | 114798-36-6 |
Description and Uses
Losartan carboxaldehyde is an intermediate aldehyde metabolite of the angiotensin II type 1 receptor antagonist, losartan . It does not block angiotensin receptors, but instead inhibits endothelial cyclooxygenase (COX)-2 expression, thereby exerting anti-inflammatory actions. At 1 μM in vitro, losartan carboxaldehyde has also been shown to block the upregulation of intercellular adhesion molecule (ICAM)-1 mRNA and COX-dependent generation of thromboxane A2 and prostaglandin F2α . Losartan carboxaldehyde can also act as a partial agonist (EC50 = 17.1 μM) of the insulin-sensitizing peroxisome proliferator-activated receptor γ in vitro.
A labelled intermediate in the synthesis of the EXP 3174, a metabolite of Losartan
Safety
| HS Code | 2933290000 |
