PorcinedynorphinA(1-13),DynorphinAPorcineFragment1-13 , BR , 72957-38-1

CAS NO.：72957-38-1

Empirical Formula: C75H126N24O15

Molecular Weight: 1603.95

MDL number: MFCD00076366

PRODUCT Properties

• Density: 1.39±0.1 g/cm3(Predicted)
• RTECS: JV7436666
• storage temp.: Inert atmosphere,Store in freezer, under -20°C
• form: Solid
• pka: 3.31±0.10(Predicted)
• color: White to off-white
• Water Solubility: Water: ≥ 60 mg/mL (37.41 mM)
• Sequence: H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-OH
• InChIKey: OVVIBUHLQIYUEU-JASZZEBFNA-N

Description and Uses

Dynorphin A(1-13), a tridecapeptide of the endogenous opioid peptides, has modest effects in reducing mild opiate withdrawal in humans. Previous studies revealed that dynorphin also potentiates the analgesic effect of morphine in morphine-tolerant rats and mice. The therapeutic potential of dynorphin A(1-13) is limited due to extensive metabolism by human metabolic enzymes resulting in an in vivo half-life of less than one minute. Chemical modifications of dynorphin A(1-13), such as N-methylation of Tyr1 and amidation of the C-terminus have been shown to be effective in protecting against the proteolytic enzymes in human plasma^[1].

Porcine dynorphin A (1-13) is a potent, endogenous κ opioid receptor agonist and is antinociceptive at physiological concentrations.

Safety

• WGK Germany: 3
• HS Code: 2933998090