PRODUCT Properties
| Melting point: | 167-168° |
| alpha | D25 -102.8° (c = 3.64 in 95% ethanol) |
| Boiling point: | 325.55°C (rough estimate) |
| Density | 1.0772 (rough estimate) |
| refractive index | 1.4300 (estimate) |
| storage temp. | -20° |
| solubility | Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 10 mg/ml). |
| form | White to off-white solid. |
| pka | 13.29±0.60(Predicted) |
| color | White |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| InChI | 1S/C15H18O4/c1-7-6-10-12(8(2)14(18)19-10)13(17)15(3)9(7)4-5-11(15)16/h4-5,7,9-10,12-13,17H,2,6H2,1,3H3/t7-,9+,10-,12-,13+,15+/m1/s1 |
| InChIKey | ZVLOPMNVFLSSAA-XEPQRQSNSA-N |
| SMILES | O1[C@H]2[C@H]([C@@H]([C@]3([C@H]([C@@H](C2)C)C=CC3=O)C)O)C(=C)C1=O |
| LogP | 0.870 |
Description and Uses
Helenalin (6754-13-8) is a novel sesquiterpene lactone which inhibits NFκB1and displays potent anti-inflammatory activity2. It suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms.3 Helenalin also inhibits telomerase and this activity may be partially responsible for its anti-tumor effects.4
Helenalin is a highly toxic compound, with hepatic and lymphatic tissues particularly vulnerable to its effects. It is believed to be responsible for the toxicity and skin irritation associated with Arnica. If enough of the plant is ingested, the helenalin produces severe gastroenteritis and internal bleeding of the digestive tract.
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P301+P310-P405-P501 |
| RIDADR | 2811 |
| WGK Germany | WGK 3 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral |
| Hazardous Substances Data | 6754-13-8(Hazardous Substances Data) |
| Toxicity | LD50 in mice, rats (mg/kg): 150, 125 orally (Witzel) |
