6β-hydroxyDexamethasone , 98% , 55879-47-5
| Pack Size | Price | Stock | Quantity |
| 1mg | RMB6423.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 259-262°C |
| Boiling point: | 613.2±55.0 °C(Predicted) |
| Density | 1.38±0.1 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | Dioxane (Very Slightly, Sonicated), Methanol (Slightly) |
| form | Solid |
| pka | 12.06±0.70(Predicted) |
| color | White to Light Yellow |
| InChIKey | RVBSTEHLLHXILB-QIKGXCFKNA-N |
| SMILES | C1[C@]2(C)[C@]3(F)[C@@H](O)C[C@]4(C)[C@](O)(C(CO)=O)[C@@H](C)C[C@@H]4[C@@H]3C[C@@H](O)C2=CC(=O)C=1 |&1:1,3,5,8,10,16,19,20,22,r| |
Description and Uses
6β-hydroxy Dexamethasone is a metabolite of dexamethasone (Item Nos. 11015 | 20340) that is more hydrophilic than the parent compound. Dexamethasone is metabolized by CYP3A4; therefore, quantification of the dexamethasone metabolites, 6α- and 6β-hydroxy dexamethasone, can be used to determine CYP3A4 enzyme activity in humans. The formation of 6-hydroxy dexamethasone metabolites is species-specific, with hamsters producing the highest amount. In rats, dexamethasone hydroxylation is sex-specific, with male rats producing metabolites in similar ratios to humans and female rats producing fewer hydroxylated metabolites than male rats.
The hydrophilic metabolite of Dexamethasone (D298800).
