13,14-dihydro-15-ketoProstaglandinD2? , 98% , 59894-07-4

CAS NO.：59894-07-4

Empirical Formula: C20H32O5

Molecular Weight: 352.47

MDL number: MFCD00065732

PRODUCT Properties

• Boiling point: 542.1±40.0 °C(Predicted)
• Density: 1.086±0.06 g/cm3(Predicted)
• solubility: DMF: 50 mg/ml; DMSO: 30 mg/ml; Ethanol: 50 mg/mlPBS pH 7.2: 2.5 mg/ml
• pka: 4.76±0.10(Predicted)

Description and Uses

13,14-dihydro-15-keto Prostaglandin D₂ (13,14-dihydro-15-keto PGD₂) is a metabolite of PGD₂ which is formed through the 15-hydroxy PGDH pathway. 13,14-dihydro-15-keto PGD₂ was recently identified as a selective agonist for the CRTH2/DP₂ receptor. It also inhibits ion flux in a canine colonic mucosa preparation. In humans, 13,14-dihydro-15-keto PGD₂ is further metabolized to give 11β-hydroxy compounds which have also undergone β-oxidation of one or both side chains. Virtually no 13,14-dihydro-15-keto PGD₂ survives intact in the urine.

13,14-Dihydro-15-keto-PGD2 is a metabolite of Prostaglandin D2 (CAT# P838575) and a selective CRTh2/DP2 receptor agonist. CRTh2/DP2 receptors play crucial roles in atopic dermatitis, asthma, and other inflammatory diseases.

Safety

• Symbol(GHS): GHS02,GHS07
• Signal word: Danger
• Hazard statements: H225-H319-H336
• Precautionary statements: P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501