PAMAM dendrimer, ethylenediamine core, generation 1.0 solution , 20?wt.%inmethanol , 142986-44-5

Synonym(s):
PAMAM dendrimer (G-1)

CAS NO.：142986-44-5

Empirical Formula: C62H128N26O12

Molecular Weight: 1429.85

MDL number: MFCD00192448

PRODUCT Properties

• Boiling point: 64.7 °C
• Density: 0.82 g/mL at 25 °C
• refractive index: n20/D 1.362
• Flash point: 52 °F
• storage temp.: 2-8°C
• solubility: Water: Soluble
• form: 20 wt.% in methanol
• color: Colorless to light yellow
• InChIKey: QVWIZHOFYGKROL-UHFFFAOYSA-N
• SMILES: C(NCCN)(=O)CCN(CCC(NCCN)=O)CCNC(=O)CCN(CCC(NCCN(CCC(NCCN)=O)CCC(NCCN)=O)=O)CCN(CCC(NCCN(CCC(NCCN)=O)CCC(NCCN)=O)=O)CCC(=O)NCCN(CCC(NCCN)=O)CCC(NCCN)=O

Description and Uses

Starburst 1st Generation (PAMAM G1.0) is a Polyamidoamine (HY-164657; PAMAM) dendrimer with amine termini that has been used as a drug delivery system in vitro. Starburst 1st Generation conjugated to di-n-dodecylamine and encapsulating 5-Fluorouracil (HY-90006) increase the solubility of 5-Fluorouracil and are cytotoxic to AGS gastric adenocarcinoma cells[1].

Safety

• Symbol(GHS): GHS02,GHS06,GHS08
• Signal word: Danger
• Hazard statements: H225-H301+H311+H331-H315-H319-H335-H370
• Precautionary statements: P210-P280-P301+P310-P303+P361+P353-P304+P340+P311-P305+P351+P338
• Hazard Codes: F,T
• Risk Statements: 11-23/24/25-39/23/24/25-36/37/38
• Safety Statements: 7-16-23-45-36/37-26
• RIDADR: UN 1230 3/PG 2
• WGK Germany: 3