ammoniumsulfatesuspension,≥100 units/mgprotein , 9027-96-7

Synonym(s):
Citrate condensing enzyme;Citrate oxaloacetate lyase (CoA-acetylating)

CAS NO.：9027-96-7

Empirical Formula: C6H5O7-3

Molecular Weight: 189.1

MDL number: MFCD00130808

EINECS: 232-821-7

PRODUCT Properties

• storage temp.: 2-8°C
• solubility: H2O: soluble1.0mg/mL, clear
• form: ammonium sulfate suspension
• color: Colorless to light yellow
• biological source: Porcine heart
• Water Solubility: H2O: soluble 1.0mg/mL, clear
• Specific Activity: ≥100units/mg protein

Description and Uses

Citrate synthase is a key mitochondrial enzyme that utilizes acetyl-CoA and oxaloacetate to form citrate and is investigated for its role in Alzheimer's disease[1]. Citrate synthase activity was measured in muscle tissue using spectrophotometry to estimate mitochondrial content, and reductions in citrate synthase and citrate can be used to develop an animal model for the silent phase of Alzheimer's disease[1][2].

Citrate Synthase from porcine heart has been used:

• to inject newt egg for determining its importance in egg activation at fertilization
• in the preparation of reaction mix to determine pyruvate carboxylase enzyme activity
• to examine whether it can induce a [Ca²⁺]increase and egg activation in unfertilized eggs

Safety

• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Storage Class: 12 - Non Combustible Liquids
• Toxicity: A fine powder used in riot control because of its property of inducing acute irritation to the eyes, to any skin abrasion and to the tissues of the respiratory passages, causing coughing and nausea.