≥98%(HPLC) , 60857-08-1

Synonym(s):
12-Deoxyphorbol-13-acetate;CCRIS 6292;NSC 623310

CAS NO.：60857-08-1

Empirical Formula: C22H30O6

Molecular Weight: 390.47

MDL number: MFCD00674138

PRODUCT Properties

• Melting point: 216-219℃
• Boiling point: 550.5±50.0 °C(Predicted)
• Density: 1.31
• storage temp.: -20°C
• solubility: Soluble in DMSO at 30mg/ml
• form: white powder
• pka: 11.40±0.70(Predicted)
• color: Off-white
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
• InChIKey: BOJKFRKNLSCGHY-HXGSDTCMSA-N
• SMILES: C[C@@H]1C[C@]2(OC(C)=O)[C@H]([C@@H]3C=C(CO)C[C@@]4(O)[C@@H](C=C(C)C4=O)[C@@]13O)C2(C)C

Description and Uses

Activation of latent reservoirs of HIV-infected cells is a treatment strategy designed to reduce viral load and eliminate the perpetuation of retroviral infection. Prostratin is a non-tumor promoting phorbol ester that potently induces HIV-1 reactivation in latent reservoirs of infected Jurkat-LAT-GFP cells with an IC₅₀ value of ~0.5 μM. Originally, prostratin was isolated from plant sources including P. prostrata, E. cornigera, and H. nutans. The effects of prostratin are mediated through activation of NF-κB via protein kinase C and by downregulation of HIV-1 receptor CD4 expression and its co-receptors CXCR4 and CCR5.

Activation of latent reservoirs of HIV-infected cells is a treatment strategy designed to reduce viral load and eliminate the perpetuation of retroviral infection. Prostratin is a non-tumor promoting phorbol ester that potently induces HIV-1 reactivation in latent reservoirs of infected Jurkat-LAT-GFP cells . [Cayman Chemical]

Safety

• PPE: Eyeshields, Gloves, type N95 (US)
• WGK Germany: 3
• HS Code: 2916200090
• Storage Class: 11 - Combustible Solids